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Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci
Internal Dataset- Authors
- Maria Gutierrez-ArcelusYuriy BaglaenkoJatin AroraSusan Hannes14 more author(s)...
- Description
In this study we sought to analyze the effects of genetic variants on gene regulation in a cell-state dependent manner during CD4 memory T cell activation. To do this, we performed an RNA-seq time series experiment on CD4 memory T cells activated with anti-CD3/CD28 beads in individuals with no autoimmune disease. We measured gene expression levels, and allele-specific expression at heterozygous sites...
- Subject
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AutoimmunityGenetic VariationHLA AntigensHLA-DQ beta-ChainsLymphocyte ActivationPromoter Regions, GeneticRNA-Seq
- Access Rights
- Free to AllFree to all with registrationApplication Required
- Local Expert
- Peter Gregersen
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IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
Internal Dataset- Authors
- Dan LiBharati MattaSu SongVictoria Nelson5 more author(s)...
- Description
The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...
- Subject
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Genetic Predisposition to DiseaseGenetic VariationInterferon Regulatory FactorsLupus Erythematosus, Systemic
- Access Rights
- Free to All
- Local Expert
- Betsy BarnesPeter Gregersen
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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
Internal Dataset- Authors
- Catherine RobertsonJamie InshawSuna Onengut-GumuscuWei-Min Chen28 more author(s)...
- Description
We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide significant (P < 5 × 10−8) regions, including 36 novel. We define credible sets of T1D-associated variants and show they are enriched in immune cell-accessible chromatin, particularly CD4+ effector T cells. Using chromatin accessibility profiling of CD4+ T cells from...
- Subject
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AllelesChromosome MappingDiabetes Mellitus, Type 1Genetic Predisposition to DiseaseGenetic VariationGenomics
- Access Rights
- Free to All
- Local Expert
- Peter Gregersen
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Subject Domain
- Genetic Variation 3
- Genetic Predisposition to Disease 2
- Alleles 1
- Autoimmunity 1
- Chromosome Mapping 1
- Diabetes Mellitus, Type 1 1
- Genomics 1
- HLA Antigens 1
- HLA-DQ beta-Chains 1
- Interferon Regulatory Factors 1
- Lupus Erythematosus, Systemic 1
- Lymphocyte Activation 1
- Promoter Regions, Genetic 1
- RNA-Seq 1